Protein Name
Cyclin-dependent kinase inhibitor 1B
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
22193
Protein Length
197
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Nucleus,Cytoplasm,Endosome;
Function
Important regulator of cell cycle progression (PubMed:8033213, PubMed:12972555). Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (By similarity). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes (PubMed:8033213). Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Gene Ontology
GO:0031464; GO:0005737; GO:0005829; GO:0005768; GO:0043231; GO:0005634; GO:0032991; GO:0051087; GO:0030332; GO:0004693; GO:0004861; GO:0030544; GO:0019901; GO:0004860; GO:0019903; GO:0044877; GO:0048102; GO:0007050; GO:0008219; GO:0071236; GO:0071285; GO:0071407; GO:0000082; GO:0007507; GO:0048839; GO:0071850; GO:0043066; GO:1905179; GO:0045786; GO:0030308; GO:0008285; GO:0051271; GO:1904030; GO:0045736; GO:0050680; GO:0060770; GO:0033673; GO:0045930; GO:0042326; GO:0045892; GO:1904706; GO:0007219; GO:0001890; GO:0010942; GO:0008284; GO:0045737; GO:0031116; GO:0045732; GO:0006813; GO:0007096; GO:1902746; GO:0043200; GO:0046686; GO:0042493; GO:0032355; GO:0009749; GO:0001666; GO:0043434; GO:0007605