CaMKinet | Result

Gene

CDKN1B

Synonyms

KIP1

Protein Name

Cyclin-dependent kinase inhibitor 1B

UniProt ID

P46527 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000228872

NCBI Gene ID

1027

Molecular Weight

22073

Protein Length

198

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1jsu)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus,Cytoplasm,Endosome;

Function

Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Gene Ontology

GO:0031464; GO:0005737; GO:0005829; GO:0005768; GO:0043231; GO:0005654; GO:0005634; GO:0051087; GO:0030332; GO:0004693; GO:0004861; GO:0030544; GO:0019901; GO:0004860; GO:0019903; GO:0044877; GO:0005072; GO:0048102; GO:0007050; GO:0071236; GO:0071285; GO:0071407; GO:0006977; GO:0000082; GO:0007507; GO:0048839; GO:0071850; GO:0043066; GO:1905179; GO:0045786; GO:0030308; GO:0008285; GO:0051271; GO:1904030; GO:0045736; GO:0060770; GO:0033673; GO:0045930; GO:0042326; GO:0045892; GO:1904706; GO:0007219; GO:0001890; GO:0045787; GO:0010942; GO:0008284; GO:0045737; GO:0031116; GO:0045732; GO:0006813; GO:0000079; GO:0007096; GO:1902746; GO:0043200; GO:0046686; GO:0042493; GO:0032355; GO:0009749; GO:0001666; GO:0043434; GO:0007605