Function
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).Isoform 2: Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).
Gene Ontology
GO:0005737; GO:0005829; GO:0016020; GO:0005654; GO:0005634; GO:0071148; GO:0071149; GO:0033613; GO:0003682; GO:0070064; GO:0008022; GO:0046982; GO:0000978; GO:0003713; GO:0003714; GO:0044212; GO:0060449; GO:0061026; GO:0000902; GO:0008283; GO:0006974; GO:0071480; GO:0071300; GO:0060242; GO:0003143; GO:0003015; GO:0035329; GO:0030216; GO:0048368; GO:0060487; GO:0030857; GO:2001237; GO:2000737; GO:0030903; GO:0048339; GO:0090263; GO:0060045; GO:0033148; GO:1902459; GO:0045944; GO:0045893; GO:0050847; GO:0065003; GO:1902036; GO:0010837; GO:0072307; GO:0050767; GO:0072091; GO:0032570; GO:0035019; GO:0001894; GO:0006367; GO:0001570