CaMKinet | Result

Gene

PLA2G4A

Synonyms

CPLA2 PLA2G4

Protein Name

Cytosolic phospholipase A2

UniProt ID

P47712 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000356436

NCBI Gene ID

5321

Molecular Weight

85239

Protein Length

749

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1bci)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine

Localization

Cytoplasm,Cytoplasmic vesicle;

Function

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Gene Ontology

GO:0005737; GO:0031410; GO:0005829; GO:0005783; GO:0005789; GO:0005794; GO:0005811; GO:0005743; GO:0005634; GO:0005509; GO:0047498; GO:0005544; GO:0004622; GO:0008970; GO:0004623; GO:0102567; GO:0102568; GO:0019369; GO:0050482; GO:0035965; GO:0071236; GO:0046475; GO:0046456; GO:0006690; GO:0006654; GO:0036151; GO:0036152; GO:0036148; GO:0036149; GO:0036150; GO:0006644; GO:0006663; GO:0042127