CaMKinet | Result

Gene

Pla2g4a

Synonyms

Cpla2 Pla2g4

Protein Name

Cytosolic phospholipase A2

UniProt ID

P47713 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSMUSP00000070868

NCBI Gene ID

18783

Molecular Weight

85222

Protein Length

748

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine

Localization

Cytoplasm,Cytoplasmic vesicle;

Function

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Gene Ontology

GO:0005737; GO:0005829; GO:0005783; GO:0005794; GO:0043231; GO:0005811; GO:0005634; GO:0048471; GO:0042588; GO:0005509; GO:0047498; GO:0005544; GO:0035035; GO:0004622; GO:0004623; GO:0102567; GO:0102568; GO:0019369; GO:0050482; GO:0071236; GO:0046697; GO:0046475; GO:0046456; GO:0001542; GO:0043065; GO:0008284; GO:0050729; GO:0031394; GO:0031340; GO:0042127; GO:0051592; GO:0010033; GO:0043129