Gene
Synonyms
PIP5K2 PIP5K2A
Protein Name
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
46225
Protein Length
406
Protein Domain
3D Structure
(PDB ID : 2ybx)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
Localization
Cell membrane,Nucleus,Cytoplasm;
Function
Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.
Gene Ontology
GO:0005776; GO:0005829; GO:0005654; GO:0005886; GO:0052811; GO:0016308; GO:0016309; GO:0005524; GO:0035855; GO:0006661; GO:0006644; GO:2000786; GO:0010506; GO:0014066