CSNK1E | Casein kinase I isoform epsilon
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
CSNK1E
Synonyms
-
Protein Name
Casein kinase I isoform epsilon
UniProt ID
P49674 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000352929
NCBI Gene ID
1028003171454
Molecular Weight
47315
Protein Length
416
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 4hok)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.1; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Nucleus;
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
Gene Ontology
GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005524; GO:0004672; GO:0004674; GO:0003723; GO:0060070; GO:0097711; GO:0032922; GO:0006281; GO:0006897; GO:0000086; GO:0032091; GO:0018105; GO:0018107; GO:0090263; GO:2000052; GO:0032436; GO:1905426; GO:0006468; GO:1903827; GO:0042752; GO:0010389; GO:0007165
 
Gene Ontology