CaMKinet | Result

Gene

NUMB

Synonyms

C14orf41

Protein Name

Protein numb homolog

UniProt ID

P49757 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000347169

NCBI Gene ID

8650

Molecular Weight

70804

Protein Length

651

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 5njj)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Membrane;

Function

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Gene Ontology

GO:0045177; GO:0016323; GO:0030136; GO:0005769; GO:0019897; GO:0005925; GO:0098978; GO:0005634; GO:0005886; GO:0045294; GO:0008013; GO:0045296; GO:0034332; GO:0007409; GO:0021670; GO:1903077; GO:0021849; GO:0030335; GO:0050769; GO:0099149