Protein Name
Dual specificity protein kinase CLK3
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
73515
Protein Length
638
Protein Domain
3D Structure
(PDB ID : 2wu6)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Isoform 1: Nucleus,Cytoplasm,Cytoplasmic vesicle,Secretory vesicle,Acrosome;Isoform 2: Nucleus speckle;
Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Gene Ontology
GO:0001669; GO:0045111; GO:0016020; GO:0016607; GO:0005654; GO:0005634; GO:0005524; GO:0042802; GO:0004674; GO:0004712; GO:0004713; GO:0003723; GO:0046777; GO:0006468; GO:0043484