Protein Name
Nuclear pore complex protein Nup153
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
153938
Protein Length
1475
Protein Domain
3D Structure
(PDB ID : 2ebq)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Nucleus,Nucleus membrane,Nucleus,Nuclear pore complex;
Function
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).
Gene Ontology
GO:0005829; GO:0043657; GO:0042405; GO:0031965; GO:0034399; GO:0005643; GO:0044613; GO:0044615; GO:0005730; GO:0005654; GO:0003677; GO:0042802; GO:0046872; GO:0008139; GO:0043495; GO:0017056; GO:0006406; GO:0046832; GO:0051292; GO:0006606; GO:0046718; GO:0075732; GO:0016032