Protein Name
E3 SUMO-protein ligase RanBP2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
358199
Protein Length
3224
Protein Domain
3D Structure
(PDB ID : 1rrp)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Localization
Nucleus,Nucleus membrane,Nucleus,Nuclear pore complex,Nucleus envelope;
Function
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830).
Gene Ontology
GO:0005642; GO:0005737; GO:1990723; GO:0005829; GO:0016020; GO:0005739; GO:0005635; GO:0042405; GO:0031965; GO:0005643; GO:0044614; GO:0044615; GO:0005634; GO:0046872; GO:0044877; GO:0008536; GO:0003723; GO:0019789; GO:0051642; GO:0006406; GO:0006607; GO:0033133; GO:0043547; GO:0006457; GO:0000413; GO:0016925; GO:0006111; GO:0001975; GO:0016032