Function
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).
Gene Ontology
GO:0005737; GO:0005829; GO:0005794; GO:0005764; GO:0016020; GO:0005634; GO:0048471; GO:0014069; GO:0033596; GO:0005096; GO:0051879; GO:0019902; GO:0042803; GO:0031267; GO:0043276; GO:0006897; GO:0007507; GO:0048009; GO:0008285; GO:0046627; GO:1901525; GO:0014067; GO:0006469; GO:0051898; GO:0032007; GO:0030178; GO:0001843; GO:0050918; GO:0016239; GO:0006606; GO:0043491; GO:0008104; GO:0051726; GO:0030100; GO:0046626; GO:0051056; GO:0016192; GO:0016032