Protein Name
Tuberin
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
201278
Protein Length
1809
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). May also play a role in microtubule-mediated protein transport (PubMed:16707451). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (PubMed:9045618).
Gene Ontology
GO:0005901; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0030425; GO:0098978; GO:0030426; GO:0043231; GO:0045121; GO:0043005; GO:0043025; GO:0005634; GO:0048471; GO:0032991; GO:0033596; GO:0005096; GO:0019902; GO:0046982; GO:0047485; GO:0007568; GO:0030030; GO:0030010; GO:0045184; GO:0050771; GO:0008285; GO:0045792; GO:0050680; GO:0010719; GO:0048147; GO:0046627; GO:0016242; GO:0043407; GO:0048550; GO:0051898; GO:0001933; GO:0032007; GO:1905563; GO:0030178; GO:0045785; GO:0060999; GO:0010763; GO:0010976; GO:0051291; GO:0051260; GO:0034394; GO:0051726; GO:0099175; GO:0051056; GO:0007165; GO:0035176