Cdkn1c | Cyclin-dependent kinase inhibitor 1C
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
Cdkn1c
Synonyms
Kip2
Protein Name
Cyclin-dependent kinase inhibitor 1C
UniProt ID
P49919 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSMUSP00000037302
NCBI Gene ID
12577
Molecular Weight
37372
Protein Length
348
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Gene Ontology
GO:0005737; GO:0005634; GO:0004861; GO:0044877; GO:0030325; GO:0007568; GO:0043010; GO:0007050; GO:0055123; GO:0060669; GO:0071514; GO:0001822; GO:0035264; GO:0030099; GO:0050680; GO:0042326; GO:0000122; GO:0042551; GO:0001890; GO:0045893; GO:0030511; GO:0007096; GO:1902746; GO:0001501; GO:0060065