Atp6v1a | V-type proton ATPase catalytic subunit A
 
Sequence Viewer
Gene
Atp6v1a
Synonyms
Atp6a1 Atp6a2 Atp6v1a1
Protein Name
V-type proton ATPase catalytic subunit A
UniProt ID
P50516 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSMUSP00000066886
NCBI Gene ID
11964
Molecular Weight
68326
Protein Length
617
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
7.1.2.2; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate
Localization
Cytoplasm;
Function
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity.
Gene Ontology
GO:0016324; GO:0005829; GO:0005902; GO:0005739; GO:0043209; GO:0005886; GO:0033180; GO:0005774; GO:0005524; GO:0046961; GO:0015991; GO:0046034; GO:0006879; GO:0036295