CaMKinet | Result

Gene

Gabrb1

Synonyms

Protein Name

Gamma-aminobutyric acid receptor subunit beta-1

UniProt ID

P50571 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSMUSP00000031122

NCBI Gene ID

14400

Molecular Weight

54100

Protein Length

474

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cell junction,Synapse,Postsynaptic cell membrane,Cell membrane;

Function

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Gene Ontology

GO:0030054; GO:0034707; GO:0005737; GO:0030425; GO:1902711; GO:0098982; GO:0005887; GO:0016020; GO:0043005; GO:0005635; GO:0005634; GO:0005886; GO:0045211; GO:0043235; GO:0045202; GO:0005253; GO:0050811; GO:0004890; GO:0022851; GO:0015276; GO:1904315; GO:0071420; GO:0021954; GO:0007268; GO:1902476; GO:0007214; GO:0034220; GO:0006811; GO:0050877; GO:0042698; GO:0042391; GO:0032570; GO:0009636; GO:0007165