BRCA2 | Breast cancer type 2 susceptibility protein
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
BRCA2
Synonyms
FACD FANCD1
Protein Name
Breast cancer type 2 susceptibility protein
UniProt ID
P51587 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000369497
NCBI Gene ID
675
Molecular Weight
384202
Protein Length
3418
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1n0w)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome;
Function
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180).
Gene Ontology
GO:0033593; GO:0005813; GO:0005829; GO:0000800; GO:0000784; GO:0005654; GO:0005634; GO:0032991; GO:0030141; GO:0043015; GO:0010484; GO:0010485; GO:0042802; GO:0002020; GO:0008022; GO:0003697; GO:0007420; GO:0007569; GO:0051298; GO:0006978; GO:0006302; GO:0000724; GO:0070200; GO:0008585; GO:0030097; GO:0043966; GO:0043967; GO:0001833; GO:0042771; GO:0007141; GO:0000281; GO:1990426; GO:0033600; GO:0006289; GO:0001556; GO:0045931; GO:0045893; GO:0032465; GO:0048478; GO:0010332; GO:0010225; GO:0010165; GO:0007283; GO:0000722
 
Gene Ontology