CCR5 | C-C chemokine receptor type 5
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
CCR5
Synonyms
CMKBR5
Protein Name
C-C chemokine receptor type 5
UniProt ID
P51681 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000292303
NCBI Gene ID
1234
Molecular Weight
40524
Protein Length
352
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1nd8)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cell membrane;
Function
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation.(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.
Gene Ontology
GO:0009986; GO:0005737; GO:0005768; GO:0009897; GO:0005887; GO:0005886; GO:0003779; GO:0019957; GO:0016493; GO:0071791; GO:0019956; GO:0004950; GO:0015026; GO:0004435; GO:0001618; GO:0006816; GO:0019722; GO:0060326; GO:0007166; GO:0007267; GO:0006968; GO:0071222; GO:0006935; GO:0019221; GO:0002407; GO:0030260; GO:0019064; GO:0007186; GO:0006955; GO:0006954; GO:0000165; GO:2000110; GO:0007204; GO:0014808; GO:0070723; GO:0023052
 
Gene Ontology