CaMKinet | Result

Gene

CLCN3

Synonyms

Protein Name

H(+)/Cl(-) exchange transporter 3

UniProt ID

P51790 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000261514

NCBI Gene ID

1182

Molecular Weight

90966

Protein Length

818

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Isoform 1: Early endosome membrane,Late endosome membrane,Cytoplasmic vesicle,Secretory vesicle membrane;Isoform 2: Golgi apparatus membrane;

Function

Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.

Gene Ontology

GO:0009986; GO:0031410; GO:0005769; GO:0031901; GO:0005768; GO:0009897; GO:0098982; GO:0098978; GO:0005794; GO:0000139; GO:0016021; GO:0005887; GO:0030285; GO:0005770; GO:0031902; GO:0016020; GO:0045335; GO:0005886; GO:0030141; GO:0042581; GO:0008021; GO:0030658; GO:0012506; GO:0005524; GO:0005254; GO:0031404; GO:0030165; GO:0046982; GO:0042803; GO:0015299; GO:0005247; GO:0072320; GO:1902476; GO:0048388; GO:0045794; GO:0006885; GO:0097401