STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Nucleus,Cytoplasm,Cytosol;

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

GO:0005829; GO:0016607; GO:0005654; GO:0005634; GO:0003700; GO:0000981; GO:1990841; GO:0046982; GO:0044877; GO:0000978; GO:0008134; GO:0009887; GO:0031100; GO:0010260; GO:0007417; GO:0051594; GO:0048565; GO:0031018; GO:0031017; GO:0006091; GO:0042593; GO:0006006; GO:0030073; GO:0001889; GO:0016331; GO:0008285; GO:1902236; GO:0000122; GO:2000675; GO:0007263; GO:0010942; GO:0008284; GO:0043388; GO:0035774; GO:0045944; GO:0043279; GO:0010157; GO:0034097; GO:0070542; GO:0051384; GO:0010040; GO:0043201; GO:0035094; GO:0033273; GO:0009611; GO:0007224; GO:0048863; GO:0006366; GO:0060290; GO:0003309