Protein Name
LIM domain kinase 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
72585
Protein Length
647
Protein Domain
3D Structure
(PDB ID : 5hvk)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Nucleus,Cell projection,Lamellipodium;
Function
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).
Gene Ontology
GO:0005737; GO:0005829; GO:0005925; GO:0030027; GO:0016020; GO:0043005; GO:0016607; GO:0005634; GO:0005524; GO:0031072; GO:0046872; GO:0046982; GO:0004672; GO:0004674; GO:0030036; GO:0038096; GO:0051444; GO:0007399; GO:0032233; GO:0045773; GO:0051496; GO:0006468; GO:0007266; GO:0007165