CaMKinet | Result

Gene

ATXN1

Synonyms

ATX1 SCA1

Protein Name

Ataxin-1

UniProt ID

P54253 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000244769

NCBI Gene ID

6310

Molecular Weight

86923

Protein Length

815

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1oa8)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Nucleus;

Function

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity).

Gene Ontology

GO:0005737; GO:0005829; GO:0042405; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0003677; GO:0042802; GO:0034046; GO:0008266; GO:0008022; GO:0043621; GO:0007420; GO:0007612; GO:0048286; GO:0007613; GO:0000122; GO:0045892; GO:0051168; GO:0006396; GO:0035176