Slc12a1 | Solute carrier family 12 member 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer
Gene
Slc12a1
Synonyms
Nkcc2
Protein Name
Solute carrier family 12 member 1
UniProt ID
P55014 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
-
NCBI Gene ID
20495
Molecular Weight
120355
Protein Length
1095
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Membrane;
Function
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
Gene Ontology
GO:0016324; GO:0009986; GO:0070062; GO:0016021; GO:0005886; GO:0015379; GO:0015081; GO:0015378; GO:0008511; GO:0006884; GO:0071475; GO:0048878; GO:0055064; GO:1902476; GO:0006821; GO:0007588; GO:0034220; GO:0001822; GO:0070886; GO:0055075; GO:1990573; GO:0006813; GO:0032978; GO:0055078; GO:0035725; GO:0006814
 
Gene Ontology