CaMKinet | Result

Gene

NR1H2

Synonyms

LXRB NER UNR

Protein Name

Oxysterols receptor LXR-beta

UniProt ID

P55055 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000253727

NCBI Gene ID

7376

Molecular Weight

50974

Protein Length

460

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1p8d)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus;

Function

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).

Gene Ontology

GO:0005737; GO:0005654; GO:0005634; GO:0090575; GO:0034191; GO:0051117; GO:0003677; GO:0001228; GO:0000981; GO:0004879; GO:0030374; GO:0046965; GO:0000978; GO:0000977; GO:0038023; GO:0003707; GO:0008134; GO:0000976; GO:0008270; GO:0030154; GO:0044255; GO:0071222; GO:0042632; GO:0055088; GO:0006629; GO:0007275; GO:0010887; GO:0120163; GO:0060336; GO:0032369; GO:0010745; GO:0048550; GO:0045861; GO:0000122; GO:0045892; GO:0032270; GO:0010875; GO:0032376; GO:0045723; GO:0090108; GO:0010884; GO:0051006; GO:0090187; GO:0090340; GO:0045944; GO:0045893; GO:0010867; GO:0048384; GO:0006367