CaMKinet | Result

Gene

CASP6

Synonyms

MCH2

Protein Name

Caspase-6

UniProt ID

P55212 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000265164

NCBI Gene ID

839

Molecular Weight

33310

Protein Length

293

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1mi9)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

3.4.22.59; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.

Localization

Cytoplasm;

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

Gene Ontology

GO:0005737; GO:0005829; GO:0005654; GO:0004197; GO:0097153; GO:0097200; GO:0008234; GO:0042802; GO:0006915; GO:0072734; GO:0030855; GO:0097194; GO:0006508; GO:0042981