Protein Name
Histone deacetylase 4
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
119040
Protein Length
1084
Protein Domain
3D Structure
(PDB ID : 2h8n)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Localization
Nucleus,Cytoplasm;
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).
Gene Ontology
GO:0031672; GO:0042641; GO:0005737; GO:0005829; GO:0000118; GO:0031594; GO:0005654; GO:0005634; GO:0017053; GO:0030018; GO:0033613; GO:0004407; GO:0042826; GO:0042802; GO:0032041; GO:0030955; GO:1990841; GO:0033558; GO:0019901; GO:0070491; GO:0000978; GO:0001085; GO:0019789; GO:0003714; GO:0008134; GO:0008270; GO:0042113; GO:0030183; GO:0014898; GO:0071260; GO:0071374; GO:0071356; GO:0006338; GO:0016575; GO:0070932; GO:0070933; GO:0006954; GO:0008285; GO:0043433; GO:0045820; GO:0010832; GO:0045668; GO:1902894; GO:0000122; GO:0045892; GO:0007399; GO:0002076; GO:0034983; GO:0008284; GO:0051091; GO:0010592; GO:0043525; GO:0033235; GO:1903428; GO:0014911; GO:0048661; GO:0045944; GO:0045893; GO:0006476; GO:0010882; GO:0040029; GO:0043393; GO:0048742; GO:0014894; GO:0042493; GO:0070555; GO:0001501