CaMKinet | Result

Gene

PRPS1

Synonyms

Protein Name

Ribose-phosphate pyrophosphokinase 1

UniProt ID

P60891 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000361512

NCBI Gene ID

5631

Molecular Weight

34834

Protein Length

318

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2h06)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.6.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)

Localization

Function

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

Gene Ontology

GO:0005737; GO:0005829; GO:0002189; GO:0005524; GO:0042802; GO:0016301; GO:0000287; GO:0042803; GO:0004749; GO:0006015; GO:0046101; GO:0007399; GO:0009116; GO:0009165; GO:0006144; GO:0006164; GO:0006221; GO:0009156; GO:0034418