CaMKinet | Result

Gene

PLN

Synonyms

Protein Name

Cardiac phospholamban

UniProt ID

P61012 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSCAFP00000036921

NCBI Gene ID

414755

Molecular Weight

6080

Protein Length

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 4kyt)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Endoplasmic reticulum membrane,Sarcoplasmic reticulum membrane,Mitochondrion membrane,Membrane;

Function

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity).

Gene Ontology

GO:0090534; GO:0031966; GO:0033017; GO:0042030; GO:0005246; GO:0086023; GO:0006816; GO:0048738; GO:0006874; GO:0032780; GO:1901877; GO:1902081; GO:1901020; GO:1901895; GO:0010459; GO:0007219; GO:0051924; GO:0086004; GO:0010881; GO:1901077; GO:0060314; GO:0086092