Protein Name
Proteasome activator complex subunit 3
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
29506
Protein Length
254
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Nucleus,Cytoplasm;
Function
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).
Gene Ontology
GO:0005737; GO:0005829; GO:0016020; GO:0005654; GO:0005634; GO:0008537; GO:0000502; GO:0061133; GO:0042802; GO:0097371; GO:0002039; GO:0006915; GO:0007049; GO:2001237; GO:0010950; GO:0043687; GO:0016579; GO:2000045; GO:0061136