HIST1H2BC | Histone H2B type 1-C/E/F/G/I
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
HIST1H2BC
Synonyms
H2BFL
Protein Name
Histone H2B type 1-C/E/F/G/I
UniProt ID
P62807 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000321744
NCBI Gene ID
301783398343834483468347
Molecular Weight
13906
Protein Length
126
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 5gt0)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Chromosome;
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Gene Ontology
GO:0005829; GO:0070062; GO:0005615; GO:0005654; GO:0000786; GO:0005634; GO:0003677; GO:0042802; GO:0046982; GO:0019731; GO:0061844; GO:0050830; GO:0002227; GO:0006334; GO:0016567
 
Gene Ontology