Protein Name
Cytochrome c
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
11704
Protein Length
105
Protein Domain
3D Structure
(PDB ID : 2b4z)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Mitochondrion intermembrane space;
Function
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
Gene Ontology
GO:0005758; GO:0070469; GO:0009055; GO:0020037; GO:0046872; GO:0006915; GO:0006123; GO:0006122