Protein Name
Eukaryotic translation initiation factor 4E
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
25053
Protein Length
217
Protein Domain
3D Structure
(PDB ID : 1ej1)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,P-body,Cytoplasm;
Function
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
Gene Ontology
GO:0033391; GO:0005737; GO:0036464; GO:0010494; GO:0005829; GO:0016281; GO:0098978; GO:0005845; GO:0000932; GO:0048471; GO:0098794; GO:0099524; GO:0032991; GO:0016442; GO:0019899; GO:0031370; GO:0070491; GO:0000340; GO:0003743; GO:0045182; GO:0001662; GO:0071549; GO:0000082; GO:0030324; GO:0045665; GO:0017148; GO:0045931; GO:0006417; GO:0099578; GO:0019827