Protein Name
Nuclease-sensitive element-binding protein 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
35924
Protein Length
324
Protein Domain
3D Structure
(PDB ID : 1h95)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Nucleus,Cytoplasmic granule,Secreted;
Function
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.
Gene Ontology
GO:0070937; GO:0005737; GO:0010494; GO:0005829; GO:0070062; GO:0005576; GO:0071204; GO:0043231; GO:0031965; GO:0005654; GO:0005634; GO:1990904; GO:0005689; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0003690; GO:0051020; GO:0003723; GO:0000978; GO:0003697; GO:0070934; GO:0000398; GO:0007219; GO:0051781; GO:0045944; GO:1903608; GO:0006355; GO:0006366