EEF1A1 | Elongation factor 1-alpha 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
EEF1A1
Synonyms
EEF1A EF1A LENG7
Protein Name
Elongation factor 1-alpha 1
UniProt ID
P68104 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000339053
NCBI Gene ID
1915
Molecular Weight
50141
Protein Length
462
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1syw)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Nucleus,Nucleus,Nucleolus,Cell membrane;
Function
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Gene Ontology
GO:0030864; GO:0005737; GO:0098574; GO:0005829; GO:0005853; GO:0070062; GO:0005576; GO:0005615; GO:1904813; GO:0016020; GO:0005730; GO:0005634; GO:0005886; GO:0032587; GO:0034774; GO:0005525; GO:0003924; GO:0019901; GO:0003723; GO:0003746; GO:0000049; GO:0071364; GO:0043312; GO:1904714; GO:0006412; GO:0006414
 
Gene Ontology