HIST1H3A | Histone H3.1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
HIST1H3A
Synonyms
H3FA
Protein Name
Histone H3.1
UniProt ID
P68431 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000366999
NCBI Gene ID
8350835183528353835483558356835783588968
Molecular Weight
15404
Protein Length
136
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1cs9)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Chromosome;
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Gene Ontology
GO:0070062; GO:0005576; GO:0016020; GO:0000228; GO:0000788; GO:0005654; GO:0000786; GO:0005634; GO:0032991; GO:0045296; GO:0031492; GO:0046982; GO:0007596; GO:0044267; GO:0006325; GO:0000183; GO:0006335; GO:0038111; GO:0045814; GO:0006334; GO:0051290; GO:0060968; GO:0060964; GO:0045652; GO:0032200
 
Gene Ontology