Protein Name
Vasodilator-stimulated phosphoprotein
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
39667
Protein Length
375
Protein Domain
3D Structure
(PDB ID : 2v8c)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cytoplasm,Cytoskeleton,Cell junction,Focal adhesion,Cell junction,Tight junction,Cell projection,Lamellipodium membrane,Cell projection,Filopodium membrane;
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity).
Gene Ontology
GO:0005923; GO:0005856; GO:0005829; GO:0030175; GO:0031527; GO:0005925; GO:0030027; GO:0031258; GO:0005886; GO:0003779; GO:0005522; GO:0017124; GO:0030036; GO:0008154; GO:0007411; GO:0001843; GO:0030838; GO:0051289