STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Cell membrane,Cell junction,Early endosome,Late endosome,Lysosome;

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:8962122, PubMed:9295051, PubMed:9103415). Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation (PubMed:9634237, PubMed:9634238, PubMed:9689100). Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (PubMed:9634237). Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (PubMed:9634238, PubMed:9689100).

GO:0031252; GO:0009986; GO:0005911; GO:0005737; GO:0031410; GO:0005769; GO:0005768; GO:0009897; GO:0030426; GO:0016021; GO:0005770; GO:0005764; GO:0005634; GO:0005886; GO:0032991; GO:0003779; GO:0019957; GO:0016493; GO:0016494; GO:0038147; GO:0019956; GO:0008144; GO:0032027; GO:0043130; GO:0031625; GO:0001667; GO:0009887; GO:0035904; GO:0007420; GO:0001569; GO:0019722; GO:0060048; GO:0060326; GO:0016477; GO:0071345; GO:0006935; GO:0038160; GO:0050966; GO:0050965; GO:0045446; GO:0061154; GO:0002064; GO:0007186; GO:0048699; GO:0007281; GO:0008354; GO:0035701; GO:0006955; GO:0008045; GO:0043217; GO:0007399; GO:0061351; GO:0022008; GO:0001764; GO:0090280; GO:0030335; GO:0120162; GO:0007204; GO:1903861; GO:1905322; GO:0050769; GO:0048714; GO:0001934; GO:0035470; GO:0051924; GO:0030334; GO:0050920; GO:0043067; GO:0050792; GO:0042098; GO:0022029; GO:0003281