Protein Name
Disks large homolog 4
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
80495
Protein Length
724
Protein Domain
3D Structure
(PDB ID : 1kef)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane,Cell junction,Synapse,Postsynaptic cell membrane,Postsynaptic density,Cell junction,Synapse,Cytoplasm,Cell projection,Axon;
Function
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.
Gene Ontology
GO:0032281; GO:0030054; GO:0030863; GO:0005737; GO:0005829; GO:0032839; GO:0043197; GO:0030666; GO:0005783; GO:0060076; GO:0031234; GO:0044224; GO:0031594; GO:0043005; GO:0044306; GO:0044309; GO:0005886; GO:0014069; GO:0098839; GO:0045211; GO:0045202; GO:0008021; GO:0033130; GO:0031697; GO:0031748; GO:0035255; GO:0019900; GO:0097109; GO:0031812; GO:0030165; GO:0008022; GO:0019903; GO:0044877; GO:0005088; GO:0097110; GO:0097113; GO:0098609; GO:0035865; GO:0007268; GO:0060997; GO:0045184; GO:0007612; GO:0000165; GO:0002091; GO:0007399; GO:0007204; GO:2000463; GO:0150012; GO:0061098; GO:0050806; GO:0098970; GO:0035418; GO:0065003; GO:0043113; GO:0097120; GO:0048169; GO:2000310; GO:0007165; GO:0016188