CCT2 | T-complex protein 1 subunit beta
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
CCT2
Synonyms
99D8.1 CCTB
Protein Name
T-complex protein 1 subunit beta
UniProt ID
P78371 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000299300
NCBI Gene ID
10576
Molecular Weight
57488
Protein Length
535
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm;
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Gene Ontology
GO:0035578; GO:0044297; GO:0005832; GO:0005829; GO:0070062; GO:0005576; GO:0005874; GO:0002199; GO:0005524; GO:0044183; GO:0031625; GO:0051082; GO:0007339; GO:0051086; GO:0051131; GO:0043312; GO:1904851; GO:1904871; GO:0051973; GO:1904874; GO:0032212; GO:0006457; GO:0050821; GO:0090666; GO:1901998
 
Gene Ontology