CaMKinet | Result

Gene

CDK16

Synonyms

PCTAIRE1 PCTK1

Protein Name

Cyclin-dependent kinase 16

UniProt ID

Q00536 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000276052

NCBI Gene ID

5127

Molecular Weight

55716

Protein Length

496

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 5g6v)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.22; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Cytoplasm,Cytoplasmic vesicle,Secretory vesicle,Cell membrane,Cell junction,Synapse,Synaptosome;

Function

Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).

Gene Ontology

GO:0030054; GO:0005737; GO:0005829; GO:0031234; GO:0015630; GO:0043005; GO:0005634; GO:0005886; GO:0008021; GO:0005524; GO:0004693; GO:0004674; GO:0006887; GO:0030252; GO:0031175; GO:0006468; GO:0061178; GO:0007283