Mecp2 | Methyl-CpG-binding protein 2
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
Mecp2
Synonyms
-
Protein Name
Methyl-CpG-binding protein 2
UniProt ID
Q00566 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
-
NCBI Gene ID
29386
Molecular Weight
53047
Protein Length
492
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Gene Ontology
GO:0000785; GO:0005829; GO:0098978; GO:0000792; GO:0000790; GO:0005654; GO:0005634; GO:0032991; GO:0003682; GO:0031490; GO:0003677; GO:0010385; GO:0019899; GO:0000400; GO:0042826; GO:0008327; GO:1990841; GO:0019904; GO:0045322; GO:0071317; GO:0035865; GO:0021549; GO:0021987; GO:0007507; GO:0021766; GO:0048286; GO:0048712; GO:1903860; GO:0061000; GO:0010629; GO:2000635; GO:0032091; GO:0000122; GO:0045892; GO:0030182; GO:0021772; GO:0014003; GO:0048709; GO:1901953; GO:1905492; GO:1903861; GO:0060999; GO:0010628; GO:1901956; GO:0031915; GO:0021740; GO:0044030; GO:0050807; GO:0042220; GO:0032355; GO:0010212; GO:0010288; GO:0014070; GO:0009314; GO:0035176; GO:0021510; GO:0021756; GO:0021794
 
Gene Ontology