Cacna1c | Voltage-dependent L-type calcium channel subunit alpha-1C
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
Cacna1c
Synonyms
Cach2 Cacn2 Cacnl1a1 Cchl1a1
Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt ID
Q01815 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSMUSP00000075021
NCBI Gene ID
12288
Molecular Weight
240138
Protein Length
2139
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cell membrane,Cell membrane,Sarcolemma,Perikaryon,Cell junction,Synapse,Postsynaptic cell membrane,Postsynaptic density,Cell projection,Dendrite,Cell membrane,Sarcolemma,T-tubule;
Function
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:14609949, PubMed:18586882, PubMed:21216955, PubMed:25368181, PubMed:28119464). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:21216955). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:14609949, PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
Gene Ontology
GO:0002095; GO:0030054; GO:0009986; GO:0005737; GO:0030425; GO:0043198; GO:0098978; GO:0016021; GO:0005887; GO:0099055; GO:0099056; GO:1990454; GO:0016020; GO:0043025; GO:0043204; GO:0005886; GO:0014069; GO:0045211; GO:0042734; GO:0032991; GO:0042383; GO:0030315; GO:0005891; GO:0030018; GO:0051393; GO:0005516; GO:0019899; GO:0008331; GO:0044325; GO:0046872; GO:0019904; GO:0051721; GO:0031369; GO:0005245; GO:0086056; GO:0086007; GO:1905030; GO:0007628; GO:0070509; GO:0017156; GO:0070588; GO:0061577; GO:0006816; GO:0060402; GO:0043010; GO:0061337; GO:0086002; GO:0006874; GO:0007268; GO:0035115; GO:0042593; GO:0030252; GO:0007507; GO:0002520; GO:0030073; GO:0098912; GO:0086045; GO:0086012; GO:0045762; GO:1904879; GO:0007204; GO:0008217; GO:0010881; GO:0086091; GO:0046620; GO:0019229; GO:0098911; GO:0006939; GO:0060083; GO:0008542
 
Gene Ontology