CaMKinet | Result

Gene

POU5F1

Synonyms

OCT3 OCT4 OTF3

Protein Name

POU domain, class 5, transcription factor 1

UniProt ID

Q01860 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000259915

NCBI Gene ID

5460

Molecular Weight

38571

Protein Length

360

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Nucleus;

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.

Gene Ontology

GO:0005737; GO:0005829; GO:0005739; GO:0005654; GO:0005634; GO:0005667; GO:0003677; GO:0003700; GO:0000981; GO:0001227; GO:0035198; GO:0003723; GO:0043565; GO:0008134; GO:0044212; GO:0000976; GO:0031625; GO:0009653; GO:0001824; GO:0003130; GO:0060913; GO:0060795; GO:0001714; GO:0042789; GO:0060965; GO:0000122; GO:0090263; GO:0060391; GO:0045944; GO:0009786; GO:0010468; GO:0090081; GO:0090308; GO:0006355; GO:0009611; GO:0035019; GO:0006366