CaMKinet | Result

Gene

Cacna1b

Synonyms

Cach5 Cacnl1a5

Protein Name

Voltage-dependent N-type calcium channel subunit alpha-1B

UniProt ID

Q02294 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

NCBI Gene ID

Molecular Weight

262256

Protein Length

2336

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 4dex)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Membrane;

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (PubMed:1317580). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Gene Ontology

GO:0043679; GO:0043198; GO:0098978; GO:0043005; GO:0043025; GO:0005886; GO:0032991; GO:0098685; GO:0005891; GO:0005524; GO:0005509; GO:0008331; GO:0051721; GO:0005245; GO:0099635; GO:0070509; GO:0006816; GO:0007268; GO:0001956; GO:0034765; GO:0045471; GO:0014070; GO:0033574; GO:0019233