MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
MAP2K1
Synonyms
MEK1 PRKMK1
Protein Name
Dual specificity mitogen-activated protein kinase kinase 1
UniProt ID
Q02750 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000302486
NCBI Gene ID
5604
Molecular Weight
43439
Protein Length
393
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 3eqd)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.12.2; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Cytoplasm,Cytoskeleton,Microtubule organizing center,Spindle pole body,Cytoplasm,Nucleus,Membrane;
Function
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
Gene Ontology
GO:0005737; GO:0005829; GO:0005769; GO:0005783; GO:0005925; GO:0005794; GO:0005770; GO:0005815; GO:0005739; GO:0005634; GO:0005886; GO:0005524; GO:0004708; GO:0008022; GO:0004672; GO:0047485; GO:0043539; GO:0004674; GO:0004712; GO:0004713; GO:0097110; GO:0000187; GO:0032147; GO:0060020; GO:0007050; GO:0048870; GO:0090398; GO:0021697; GO:0006935; GO:0060502; GO:0070371; GO:0060324; GO:0007507; GO:0030216; GO:0060711; GO:0000165; GO:0008285; GO:0010629; GO:0030182; GO:0018107; GO:0060674; GO:0050772; GO:0070374; GO:0010628; GO:1903800; GO:0071902; GO:0045893; GO:0006468; GO:0048679; GO:2000641; GO:0090170; GO:0032872; GO:0007165; GO:0023014; GO:0031098; GO:0048538; GO:0030878; GO:0060440
 
Gene Ontology