Protein Name
cAMP-responsive element modulator
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
37006
Protein Length
345
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Nucleus;Isoform 6: Cytoplasm,Nucleus;
Function
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
Gene Ontology
GO:0005737; GO:0005634; GO:0005667; GO:0008140; GO:0003677; GO:0000981; GO:0001227; GO:0000977; GO:0030154; GO:0006631; GO:0006006; GO:0006687; GO:0007275; GO:0000122; GO:0045944; GO:0042752; GO:0006355; GO:0048384; GO:0048511; GO:0007165; GO:0007283