Protein Name
Lactoylglutathione lyase
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
20778
Protein Length
184
Protein Domain
3D Structure
(PDB ID : 1bh5)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
(R)-S-lactoylglutathione = glutathione + methylglyoxal
Function
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.
Gene Ontology
GO:0005737; GO:0005829; GO:0070062; GO:0005634; GO:0005886; GO:0004462; GO:0008270; GO:0005975; GO:0006749; GO:0009438; GO:0043066; GO:0030316; GO:0006090; GO:0006357