MXD1 | Max dimerization protein 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
MXD1
Synonyms
MAD
Protein Name
Max dimerization protein 1
UniProt ID
Q05195 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000264444
NCBI Gene ID
4084
Molecular Weight
25254
Protein Length
221
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1e91)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.
Gene Ontology
GO:0005829; GO:0005739; GO:0000790; GO:0005654; GO:0005634; GO:0003700; GO:0000981; GO:0001227; GO:0046983; GO:0000978; GO:0003712; GO:0003714; GO:0008283; GO:0007275; GO:0000122
 
Gene Ontology