Protein Name
Hormone-sensitive lipase
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
116598
Protein Length
1076
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)a monoacylglycerol + H2O = a fatty acid + glycerol + H(+)
Localization
Cell membrane,Membrane,Caveola,Cytoplasm,Cytosol;
Function
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Gene Ontology
GO:0005901; GO:0005829; GO:0005811; GO:0033878; GO:0019901; GO:0017171; GO:0004806; GO:0008203; GO:0046340; GO:0016042; GO:0042758; GO:0006468; GO:0019433