Protein Name
Caldesmon
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
93231
Protein Length
793
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cytoskeleton,Cytoplasm,Myofibril,Cytoplasm,Cytoskeleton,Stress fiber;
Function
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).
Gene Ontology
GO:0030478; GO:0015629; GO:0005856; GO:0005829; GO:0043231; GO:0030016; GO:0005886; GO:0003779; GO:0045296; GO:0005516; GO:0017022; GO:0005523; GO:0006936